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Methods of Treating Muscular Dystrophy
Background
Duchenne muscular dystrophy (DMD) affects 1 in 3500 live male births with patients suffering from chronic muscle degeneration and weakness. Clinical symptoms are first detected between the ages of 2 and 5 years and, by the time the patient is in their teens, the ability for independent ambulation is lost. Death typically occurs in the patient...
Published: 11/5/2024
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Inventor(s): Dean Burkin, Ryan Wuebbles, Praveen Gurpur, Stephen Kaufman
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Fungal Antibody for sample testing
Background
Fungi infection is considered a threat to human and environmental health on a global level. There is a large variance of environmental and physiological conditions contributing to the development of fungal diseases, which creates a broad need worldwide to diagnose fungal infections accurately and rapidly. The most common human infections...
Published: 8/23/2023
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Inventor(s): Thomas Kozel, Breeana Hubbard, Amanda Burnham-Marusich, Alex Kvam
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Development of Melioidosis Subunit Vaccines
Background:
Burkholderia psuedomallei , the etiologic agent of melioidosis, causes severe disease in both humans and animals. Melioidosis is an emerging bacterial infectious disease that is being increasingly recognized in tropical regions around the world. Diagnosis and treatment of melioidosis can be challenging and no commercial vaccines currently...
Published: 1/18/2024
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Inventor(s): Paul Brett, Mary Burtnick
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Administration of Nootropic Agents for Enhancing Neuroprotective Signaling in Parkinson’s Disease
Background
Parkinson’s Disease (PD) is a chronic, neurodegenerative disease, caused by the progressive loss of midbrain dopamine neurons in the substantia nigra, which sends axons to the striatum. Approximately 1% of Americans are afflicted with PD, which give rise to more than $14 billion in medical-related costs each year. Symptoms include...
Published: 10/14/2024
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Inventor(s): Raul Dagda, Ruben Dagda
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Compositions acting as (pro)renin receptor antagonists for the treatment of non-alcoholic fatty liver disease
Background
Non-alcoholic fatty liver disease (NAFLD) is an umbrella term for a range of liver conditions where excess fat is stored in the liver, and affects people with little to no alcohol use. Non-alcoholic steatohepatitis (NASH) is a potentially serious form of the disease that includes liver inflammation and potential scarring, cirrhosis, and...
Published: 1/30/2023
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Inventor(s): Yumei Earley
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Model-Based Spectral Library for Bacterial Identification
Background
It is essential to develop more efficient diagnostic methods to mitigate the spread infectious diseases. Current methods of bacterial identification use matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) which is protein based mass spectra that cannot differentiate closely related bacterial species....
Published: 8/2/2023
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Inventor(s): So Young Ryu, David Goodlett, George Wendt
Keywords(s): Software
Category(s): Technology Classifications > Software, Technology Classifications > Life Sciences
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Cyclic dominant negative competence stimulating peptide analogs to treat Streptococcus pneumoniae infections
Background
Streptococcus pneumoniae (pneumococcus) is a bacterial pathogen responsible for many diseases in humans including pneumonia, meningitis, sepsis, and otitis media. It is a prevalent source of health and economic burden, with a death toll of >22,000 a year and >$3.5 billion in direct medical costs in the US alone. Concerns for current...
Published: 4/26/2023
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Inventor(s): Yftah (Yiftah) Tal-Gan (Talgan), Gee Lau, Yifang Yang
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Lateral Flow Immunoassay (LFI) for the Rapid Diagnosis of Plague
BackgroundIn the 14th century, plague was the cause of a pandemic wiping out 60% of Europe’s population. The bacterium responsible, Yersinia pestis, utilizes wild rodents as a natural reservoir and is primarily transmitted by fleas to other animal and human hosts. If administered early, antibiotics are effective at treating plague, but delayed...
Published: 2/2/2023
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Inventor(s): David AuCoin, Marcellene Hollingsworth
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Antigen Detection Assay for Early Point-of-Care Diagnosis of Zaire ebolavirus
Background The Ebola virus (EBOV) outbreak in West Africa from 2013 to 2016 and the multiple outbreaks in Democratic Republic of the Congo during 2018 have highlighted the need for a sensitive and rapid EBOV diagnostic test. Ideally, an EBOV Rapid test allows for point-of-care (POC) screening of patients and offers reliable sensitivity to support earlier...
Published: 2/2/2023
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Inventor(s): David AuCoin, Marcellene Hollingsworth
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Application to Control Shiga-toxin producing E. Coli O 157:H7, O26, O45, O103, O111, O121, and O145.
BackgroundBacterial resistance has developed towards antibiotics and chemical sanitizers due to their mass applications in food. Research is beginning to show that bacteria such as E. coli and Salmonella have both become resistant to lactic and peroxyacetic acid solutions, commonly used antimicrobial intervention in meat harvesting and processing plants....
Published: 8/22/2023
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Inventor(s): Amilton de Mello, Erica Shebs
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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