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Lateral Flow Immunoassay (LFI) for the Rapid Diagnosis of Plague
BackgroundIn the 14th century, plague was the cause of a pandemic wiping out 60% of Europe’s population. The bacterium responsible, Yersinia pestis, utilizes wild rodents as a natural reservoir and is primarily transmitted by fleas to other animal and human hosts. If administered early, antibiotics are effective at treating plague, but delayed...
Published: 2/2/2023
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Inventor(s): David AuCoin, Marcellene Hollingsworth
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Antigen Detection Assay for Early Point-of-Care Diagnosis of Zaire ebolavirus
Background The Ebola virus (EBOV) outbreak in West Africa from 2013 to 2016 and the multiple outbreaks in Democratic Republic of the Congo during 2018 have highlighted the need for a sensitive and rapid EBOV diagnostic test. Ideally, an EBOV Rapid test allows for point-of-care (POC) screening of patients and offers reliable sensitivity to support earlier...
Published: 2/2/2023
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Inventor(s): David AuCoin, Marcellene Hollingsworth
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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Use of in vivo Microbial Antigen Detection (InMAD) with human biological fluids for detection of circulating antigens
Background
Diagnosis of an infection in a timely manner is essential for proper therapeutic administration and more effective treatments, especially for diseases with non-specific early symptoms. Acute infections are typically diagnosed by identifying microbial antigens directly from patient samples. However, microbes do not replicate to high levels...
Published: 4/26/2023
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Inventor(s): David AuCoin, Thomas Kozel, Claire Smalley
Keywords(s): Life Sciences
Category(s): Technology Classifications > Life Sciences
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